PAK1 and nervous system disorder: Notably, Pak1 activity contributes to cytoskeletal reorganization underlying dendritic spine plasticity and has been implicated in a spectrum of neurological diseases and disorders (Allen et al., 2009; Kichina, Goc, Al‐Husein, Somanath, & Kandel, 2010; Ma, Yang, Frautschy, & Cole, 2012; Nikolic, 2008).