APP and Alzheimer disease: Increasing evidence has indicated that the turnover of beta‐amyloid precursor protein (APP), Aβ metabolism (Nixon, 2007; Pickford et al., 2008; Yang et al., 2011) and MAPT protein degradation (Kruger, Wang, Kumar, & Mandelkow, 2012; Schaeffer et al., 2012; Wang et al., 2009) are mainly regulated by ALP, and ALP impairment plays important roles in AD pathogenesis (Nixon & Yang, 2011; Orr & Oddo, 2013).