In tauopathy mice, TFEB overexpression mediated by AAV delivery or transgene targeted hyperphosphorylated and misfolded MAPT for degradation (Polito et al., 2014), reversed learning deficits (Wang, Wang, Carrera, Xu, & Lakshmana, 2016) and reduced MAPT spreading (Martini‐Stoica et al., 2018). This evidence concerns the gene TFEB and tauopathy.