We have showed that (i) antitumor effect of ß-lap in a concentration-dependent manner in HNSCC tumor cells, (ii) combination of 5-FU+ß-lap results in significant inhibition of NQO1 protein and Bcl-2 protein, (iii) combination-based FNQ-MSN demonstrated a significant reduction in the tumor burden in HNSCC xenograft. This evidence concerns the gene BCL2 and head and neck squamous cell carcinoma.