Regarding tumor cells, the expression of PD-L1 and p53 is positively correlated, because wild-type p53 is rapidly degraded (~0.5h); however, as the resolution time of variant p53 protein is delayed (›2h) and the protein is accumulated in the nucleus, the variant p53 protein is identified as overexpression [16, 17]. This evidence concerns the gene CD274 and neoplasm.