Of all the dysregulations that contribute to cancer progression, p53 mutation is the most frequent alteration with the greatest impact on the development of human cancers, and its inactivity is a universal phenomenon observed in more than half of the human cancers.6 p53 has a pivotal role in inducing cell growth arrest, senescence, and apoptosis,7 thus, restoration of its activity seems undeniably to be an important step in preventing every kind of neoplasia and cancers8,9 making it a suitable target for discovery of novel cancer treatment strategies. The gene discussed is TP53; the disease is cancer.