The secreted cytokines that was accompanied with PGE2 could promote the activation of beta-catenin (β-catenin) in tumor cells that finally led to CSCs generation.116,118 Both TA-MSCs and N-MSCs could create new CSCs by applying the above mentioned procedures.119 In addition, MSCs could secrete a wide array of regulatory molecules such as CXCL1, 5, 6, 7, and 8 which are ligands for the chemokine receptor CXCR2. The gene discussed is CXCR2; the disease is neoplasm.