The reciprocal interaction between tumor cells and MSCs may induce MSCs to express ligands of CCR2 and CXCR2, and also CCL5.128 Among the chemokine/ chemokine receptors that are stimulated by MSCs, the CCL2/CCR2 axis has a crucial role in acquisition of metastatic properties by tumor cells. This evidence concerns the gene CCL2 and neoplasm.