It is noteworthy that, the CXCR2/CXCR2 ligand biological axis plays an important role in supporting the CSCs generation.116 Moreover, IL-6, CCL5, bone morphogenetic proteins, and also the expression of chemokine receptors CXCR4 and CXCR7 have also been implicated in the creation of CSCs in various types of cancer.120,121 MSCs also express several microRNA (miRNA) profiles which can be involved in the expansion of CSCs122 including MiR-302, MiR-21, MiR-106b-25, MiR-181, MiR-495, MiR9/9*, MiR-22, MiR-328-3p, MiR-214, MiR-130b, and MiR-199a-3p (Figure 2).123,124. Here, CXCR2 is linked to cancer.