FGFR4 and colorectal cancer: The tumor-associated fibroblast (TAFs)/CAFs as well as myofibroblasts can originate from MSCs and play an important role in inducing and maintaining the inflammatory responses through releasing of pro-inflammatory mediators leading to the activation of EMT process (Figure 1).81,105 In addition, CAFs have been shown markedly to exert higher expression of fibroblast growth factor receptor 4 (FGFR4) by which induce EMT process in colorectal cancer cell lines.106,107