Although a few researchers have suggested that MMP-1 plays a more important role than MMP-2 in the migration, remodelling, and invasiveness of GBM, it has been shown that MMP-2 plays a vital role in the virulent progression of cancer by contributing to three vital processes: angiogenesis, metastasis, and invasion.36-39 Angiogenesis is the normal developmental process of new blood vessels from already existing ones, which serves as an imperative factor in the wound-healing process and in the female reproductive cycle. This evidence concerns the gene MMP2 and glioblastoma.