No significant differences in tumor morphology, size, and number, as well as life expectancy, were observed between Sesn2-/-;KrasLSL-G12D and Sesn1-/-;Sesn2-/-;KrasLSL-G12D mice, indicating that Sesn1 does not contribute to the suppression of tumor growth in Sesn2-deficient animals in the KrasG12D-based mouse model (Figure 3B–3D). The gene discussed is SESN2; the disease is neoplasm.