MCPH1 and neoplasm: This study also suggests MCPH1 is a tumor suppressor in EGFR activated LUAD, however the lack of increasing significance in Kaplan Meier plots with additional affected genes (including TP53), and the decrease in median survival of the unaltered curves over total LUAD is perplexing (Table 8, Figure 6) possibly suggesting, like NUDCD3, a narrow window of expression is necessary to maintain mitotic capability or that DDR capability is necessary for EGFR activated tumor cells to replicate and survive.