DKC1 upregulation is associated with the poor prognosis of patients with prostate cancer,27 hepatocellular carcinoma,28 and neuroblastoma.29 Meanwhile, DKC1 acts as a tumour suppressor and inhibits the development of pituitary tumours by downregulating the translational level of p27.30 In this study, we will explore the role of DKC1 in CRC progression. Here, DKC1 is linked to Familial prostate cancer.