HIF-1α-VEGF pathway is a classical signal pathway that can regulate tumour angiogenesis and metastasis.24 To explore whether DKC1 has an effect on HIF-1α-VEGF pathway further, we performed Western blot analysis and real-time PCR to verify the HIF-1α and VEGF protein and mRNA expression levels when DKC1 was knockdown or overexpression. The gene discussed is DKC1; the disease is neoplasm.