More importantly, Ki-67, a proliferation marker, was significantly decreased in the IM-treated GIST T1 xenograft (p < 0.0001) and TAS-116-treated GIST T1, R8, and R9 xenografts (p < 0.0001, =0.0005, and =0.0326, respectively) (Fig. 4a, b). The gene discussed is MKI67; the disease is gastrointestinal stromal tumor.