FLCN and colorectal carcinoma: Interestingly, all five patients carried the same germline mutation with a duplication in the poly (C)8 tract of the FLCN gene, suggesting a possible genotype-phenotype relation.11 To further explore the relation between germline FLCN mutations and CRC, the FLCN gene was analysed in 50 patients with familial CRC without an identifiable genetic cause.