IGF1R and neoplasm: Clinical and/or molecular data (including H3.3 but not IDH status) were available in 77/103 pHGGs, of whom nine harboured H3.3 mutation (H3.3G34R in eight, H3.3K27M in one), 47 expressed wild-type H3.3 (data unavailable in 21) with no difference in distribution of these cases between negative/weak and moderate/high IGF-1R tumours (p = 0.55, Fig. 1d), although numbers were very small.