We first set to replicate the previously observed human genetic association findings of BDKRB2 and to extend our study to the other KKS genes, the KNG1 (Kininogen 1, coding for the bradykinin peptide) and the BDKRB1. Since both strong acute stressful events and chronic stress, especially in the form of psychosocial stress, are well-known risk-factors for anxiety disorders, we then investigated whether acute or chronic stress affects brain bradykinin receptor expression. This evidence concerns the gene KNG1 and anxiety disorder.