MAPK8 and acute lymphoblastic leukemia: In T-cell acute lymphoblastic leukemia (T-ALL), the collagen-binding integrin α2β1 promotes doxorubicin resistance by maintaining the levels of anti-apoptotic protein, myeloid cell leukemia-1 (Mcl-1) through the inhibition of the c-Jun N-terminal Kinase (JNK) activation6.