Cluster 1, defined as NFAT1hiT-bethiCD4+ T cells was present at a lower frequency in patients with early MS compared to healthy controls (Fig. 4d,e), whereas the abundance of CCR7+T-bet−CD4+ T cells (cluster 13) was higher in patients with early MS (Fig. 4d,e). Here, CCR7 is linked to myeloid sarcoma.