However, the practitioners’ expertise in regional pharmacovigilance centres and the specific review of all cases by an endocrinologist warrant the accuracy of a diagnosis of hypophysitis and a good assessment of patients’ clinical histories and condition, but it must be acknowledged that, when detailed ACTH levels or stimulation tests to confirm primary versus secondary adrenal insufficiency were not available (10 cases), reliance on imperfect secondary markers was made. The gene discussed is POMC; the disease is Adrenal insufficiency.