NDUFS2 and nutritional deficiency disease: Our list of Bonferroni-significant hypomethylated genes included NDUFS2 (NADH:Ubiquinone oxidoreductase core subunit S2; Supplementary Fig. 5a), which encodes a subunit of mitochondrial complex I that has recently been implicated in the development of malnutrition-related fatty-liver in rats37.