For a treatment naïve, ECOG 0 ccRCC patient with “intermediate/poor” risk per IMDC, who is determined to need systemic therapy and has no contraindication to receiving either an IO or an anti-VEGF therapy, 78% recommend treatment with nivolumab/ipilimumab, 17% of the subcommittee recommend treatment with axitinib/pembrolizumab, and 6% recommend ICI monotherapy. Here, VEGFA is linked to nonpapillary renal cell carcinoma.