In the responders, the main SjS-relevant pathways, including BCR, chemokine, IFN-γ, IL-12, and T cell-receptor signaling pathways, were significantly downregulated at week 12 after rituximab therapy (all P < 0.05), and the key cellular components (B cells, CD4+ T cells, CD8+ T cells, TFH cells, and NK cells) also diminished (all P < 0.05). Here, CD8A is linked to Schwartz-Jampel syndrome.