In univariate and multivariate analyses, NEDD4 expression, tumor grade, and nodal status were three independent factors related to the OS rate of BC (Table 2 (a); HR = 2.353, 95% CI = 1.550 to 3.572, P < 0.001; HR = 2.003, 95% CI = 1.333 to 3.007, P = 0.001; HR = 2.105, 95% CI = 2.212 to 4.360, P < 0.001, univariate analyses, respectively; HR = 2.134, 95% CI = 1.394 to 3.268, P < 0.001; HR = 2.186, 95% CI = 1.443 to 3.310, P < 0.001; HR = 2.678, 95% CI = 1.818 to 3.970, P < 0.001, multivariate analyses, respectively). Here, NEDD4 is linked to breast cancer.