NEDD4 and ductal breast carcinoma in situ: Additionally, as the median NEDD4 IRS of ANT, DCIS, IDC, and BCLNM gradually increased, differences between indicated subtypes of BC tissues reached statistical significance (Fig. 3b, DCIS vs. ANT, P = 0.007; IDC vs. ANT, P < 0.001; BCLNM vs. ANT, P < 0.001; IDC vs. DCIS, P = 0.01; BCLNM vs. DCIS, P < 0.001; BCLNM vs. IDC, P = 0.016).