In support of our results, analyses of the 327 BC patient samples in GSE20685 revealed that NEDD4 mRNA expression is highly prognostic of OS (P = 0.04835) and distant metastasis-free survival (P = 0.0033) in the ER-negative patient population (Additional file 6: Figure S5c,d). The gene discussed is NEDD4; the disease is breast cancer.