NEDD4 and neoplasm: In support of the hypothesis that NEDD4 correlated with tumor progression, the NEDD4 expression rate in TNM stage I was 52.7%, which then increased up to 64.3% in stage II and 77.5% in stage III (Fig. 3f, stage II vs. I, χ2 = 4.402, P = 0.042; stage III vs. І, χ2 = 12.215, P < 0.001; stage III vs. II, χ2 = 4.998, P = 0.025).