Last, univariate and multivariate Cox regression analyses suggested that NEDD4 expression and tumor grades were independent risk factors for relapse in BC patients with invaded lymph nodes (Table 2 (c); HR = 2.512, 95% CI = 1.460 to 4.321, P = 0.001; HR = 1.814, 95% CI = 1.162 to 2.932, P = 0.009; HR = 1.798, 95% CI = 1.162 to 2.780, P = 0.008, univariate analyses, respectively; HR = 2.834, 95% CI = 1.636 to 4.911, P < 0.001; HR = 2.033, 95% CI = 1.293 to 3.197, P = 0.002; HR = 1.861, 95% CI = 1.143 to 3.029, P = 0.013, multivariate analyses, respectively). Here, NEDD4 is linked to breast cancer.