With regard to DFS, using a Cox regression model, we found that NEDD4 expression, lymph nodal status, and tumor grade were three independent factors related to DFS (Table 2 (b); HR = 2.407, 95% CI = 1.667 to 3.475, P < 0.001; HR = 3.762, 95% CI = 2.771 to 5.108, P < 0.001; HR = 1.752, 95% CI = 1.222 to 2.510, P = 0.002, univariate analyses, respectively; HR = 2.185, 95% CI = 1.507 to 3.162, P < 0.001; HR = 3.289, 95% CI = 2.310 to 4.683, P < 0.001; HR = 1.796, 95% CI = 1.246 to 2.589, P = 0.002, multivariate analyses, respectively). Here, NEDD4 is linked to neoplasm.