IKZF1 and leukemia: It has been reported that deregulation of IKAROS, the founding member of the family encoded by the Ikzf1 gene, results in leukemia in both mice and human [45], whereas downregulation of EOS, encoded by the Ikzf4 gene, induces a regulated conversion of Tregs into T helper-like cells that are capable of secreting proinflammatory cytokines in response to specific inflammatory signals [20].