Associated polymorphisms with hypospadias were found in DGKK, SRD5A2, ESR1, ESR2, FGF8, FGFR2, HSD17B3, MID1, CYP1A1, ATF3, MAMLD1, GSTM1, GSTT1 and AR [12]. This evidence concerns the gene MAMLD1 and hypospadias.