NPPB and pulmonary edema: All responded well to targeted therapies without pulmonary edema occurrence (See Additional file 1: Figure S1), no symptoms such as hemoptysis or pink frothy sputum occurred among our patients when given targeted drugs, NT-proBNP levels decreased, and their arterial oxygen saturation and DLCO got improved, some patients had no supplemental oxygen requirement and maintained oxygen saturation > 95% after treatments.