This study was the first to find that the expression levels of NGF and TrkA in the gastric mucosa of FD patients are significantly higher than those in the healthy controls and are positively correlated with the severity of postprandial fullness, early satiety, and epigastric pain; this suggests that the visceral hypersensitivity of FD may be related to NGF/TrkA. Here, NGF is linked to Fabry disease.