Although the exact cause of AD is not yet understood, numerous literatures have suggested the involvement of several factors for the development of the disease, including low levels of acetylcholine (ACh) in the hippocampus and cortex area of the brain, the deposition of amyloid β (Aβ) peptide, the neurofibrillary tangles (p-Tau), and the oxidative stress, which is recently proved to play vital roles in the pathogenesis of AD.5–7. The gene discussed is MAPT; the disease is Alzheimer disease.