It has been reported that barbaloin treatment can inhibit the levels of P‐MAPK14 and CDC25B in non‐small cell lung carcinoma, and suppress cell proliferation and migration consequently.38 In this study, it was demonstrated that P‐MAPK14 and CDC25B expressions in ccRCC were significantly higher than those in adjacent healthy tissues. The gene discussed is CDC25B; the disease is nonpapillary renal cell carcinoma.