It has been demonstrated that p38 can bind to and phosphorylate CDC25B,21 and activation of p38 might phosphorylate CDC25B at Ser101, leading to the rapid degradation of CDC25B and cell cycle arrest.37 Here, it was found that the level of MAPK14 phosphorylation in ccRCC tissues was higher than that of the healthy tissues, and P‐MAPK14 could affect the stability of CDC25B. The gene discussed is MAPK1; the disease is nonpapillary renal cell carcinoma.