To determine the upstream genes promoting MAPK14 phosphorylation, genes that phosphorylated MAPK14 at the transcription level in the 72 pairs of ccRCC and adjacent healthy tissues from TCGA database were analyzed, and it was found that many genes were highly expressed in ccRCC, which might facilitate the phosphorylation of MAPK14. Here, MAPK14 is linked to nonpapillary renal cell carcinoma.