The predicted probability for detecting ESCC was as follows: PRE (P = ESCC,6‐makers) =1/(1 + EXP (−(−3.592 + 0.12 × HCCR+0.086 × MDM2+0.052 × C‐myc + 0.799 × miR‐21 + 0.127 × miR‐223 − 0.942 × miR‐375))). This evidence concerns the gene MDM2 and esophageal squamous cell carcinoma.