A panel of seven TAAbs (p53, p62, HCCR, C‐myc, MDM2, hnRNPA2B1, and NICD), for the detection of ESCC with the highest coincidence rate for detection of ESCC, was established by logistic regression analysis and step‐by‐step optimization. Here, TP53 is linked to esophageal squamous cell carcinoma.