The possibility for diagnosis as ESCC was PRE (P = ESCC, 4 TAAbs) = 1/(1 + EXP (−(−3.408 + 0.095 × HCCR+0.109 × MDM2 + 0.045 × C‐myc + 0.052 × p53))). This evidence concerns the gene TP53 and esophageal squamous cell carcinoma.