Dong et al demonstrated that a significantly higher number of ESCC patients were detected positive for combing CDC25B‐Abs, CEA, SCC, and CYFRA21‐1 (64.2%) compared to the panel of CEA, SCC‐Ag, and CYFRA21‐1 (41.0%).36 The gene discussed is SERPINB3; the disease is esophageal squamous cell carcinoma.