As previously reported, the differential expression of lncRNAs is determined by upstream transcription factors.31 ZEB1 acts as a classical transcriptional inducer of EMT in many cancers.13, 14, 37 In this study, we found that ZEB1 could act as a transcription factor that binds LINC00511 in its promoter region to positively induce its expression, which completes the LINC00511/miR‐524‐5p/YB1/ZEB1 positive feedback loop. Here, ZEB1 is linked to cancer.