The findings of the current study suggest that the impaired feed‐forward loop linking Nrf2, p62 and autophagy is a critical mechanism for the out‐of‐balance redox homeostasis induced by hyperglycaemia in type 1 diabetes as illustrated (Figure 5), which eventually result in the development of DCM. The gene discussed is SQSTM1; the disease is familial dilated cardiomyopathy.