Simultaneously, the cardiac proteins expression of Bax and cleaved caspase 3 in diabetes significantly increased compared with controls, and apoptotic cell death was significantly increased despite of moderate and significant increase of cardiac Bcl‐2in the diabetic heart (all P < .05 D vs C), and ALP treatment effectively reversed all these changes except that it did not significantly affect the increases in cardiac Bcl‐2 expression in diabetes (all P < .05 DA vs D) (Figure 1G‐J). The gene discussed is CASP3; the disease is diabetes mellitus.