Through western blot analysis, we observed that knocking down BACE2 suppressed EMT stimulated by TGFβ1 (10 ng·mL−1) in both U87MG and U251 cells, which indicated that BACE2 may be stimulated by TGFβ1 in glioma cells (Fig. 6D). This evidence concerns the gene BACE2 and central nervous system cancer.