This study reports TGFβ1 stimulates beta‐site APP‐cleaving enzyme 2 (BACE2) expression through Smad‐dependent signalling, which modulates TNF‐α‐induced NF‐κB activity through the PP1A/IKK pathway to promote tumorigenesis in glioma cells. The gene discussed is NFKB1; the disease is central nervous system cancer.