On the other hand, activated autophagy mediates drug resistance and survival in some cancer cells.8, 9 BNIP3 (Bcl‐2/adenovirus E1B 19 kD protein‐interacting protein 3) is a pro‐cell death member of the Bcl‐2 family and contains only the BH3 domain. This evidence concerns the gene BNIP3 and cancer.