Moreover, deletions of the N-terminus (Δ1, deleting the N-terminal Coiled-coil-PDZ1-PDZ2 region), PDZ domains (Δ2 and Δ5, deleting PDZ1-PDZ2 or PDZ3-PDZ4 region respectively), or the linker region (Δ3) could not completely disrupted the BC-PC surfaces localization (Fig 7B, 7C and 7E and S10B Fig). The gene discussed is PC; the disease is breast cancer.