DLG5 and breast cancer: Systematically deleting domains or fragments of Dlg5 revealed that the deletion of the C-terminal region (Δ4, deleting C-terminal PDZ3-PDZ4-SH3-GUK region) and the deletion of the SH3 domain (Δ7) or the GUK domain (Δ8) caused complete loss of BC-PC surface localization (Fig 7D and 7F and S10D Fig).