Multiple immunohistochemical staining was performed showing positive SMA and HMB45 results in all 61 (100%) cases as well as positive ER (9 TSC-LAM, 38 S-LAM) and PR (8 TSC-LAM, 39 S-LAM) results in 47 (77%) cases respectively. The gene discussed is PMEL; the disease is lymphangioleiomyomatosis.