TSC1 and lymphangioleiomyomatosis: Conversely, no germline variant was detectable in the 2 patients with clinical diagnosis of TSC-LAM although somatic mutations were found in both of them, patient ID076 carrying a somatic nonsense mutation in TSC1 and patient ID183 carrying 2 somatic mutations in TSC2 (a deletion of exon 34 and an insertion of exon 41 in TSC2 from two separate kidney biopsies and both of them causing frameshift mutations).