However, the invasiveness, potential risks, and impracticality of this procedure have prompted the exploration of alternative noninvasive diagnostic approaches, including radiological techniques (e.g., liver ultrasonography, controlled attenuation parameter [CAP], transient elastography [TE], computerized tomography [CT], magnetic resonance imaging [MRI], magnetic resonance elastography [MRE]), and liver biomarkers (e.g., cytokeratin-18 fragments [CK-18], AST-to-platelet ratio index [APRI], fibrosis-4 [FIB-4]) to evaluate hepatic steatosis, fibrosis, and cirrhosis [12–16]. This evidence concerns the gene KRT18 and fibrosis.