SERPINE1 and delirium: We, therefore, sought to determine if plasma biomarkers of inflammation (interleukins 6 and 8 [IL-6, IL-8][31, 32], soluble tumor necrosis factor receptor I [sTNFRI])[26], coagulation (Protein C)[26], endothelial activation (plasminogen activating inhibitor-1 [PAI-1])[25], and BBB injury (S100B)[33] were associated with ED delirium duration in older ED patients admitted to the hospital.