CD4 and disease arising from reactivation of latent virus: In vitro, latent infection can be established through multiple pathways: direct infection of resting CD4+ T cells (pre‐activation latency 4), infection of an activated cell which survives and reverts to a resting state (post‐activation latency) 5 or infection of a cell transitioning from an effector memory to central memory phenotype 6, 7.