S1PR1 and cardiac hypertrophy: Pharmacological activation of S1pr1 by S1pr1 agonist, SEW2871 (5 mg/kg/d) for 4 weeks significantly reduced cardiac hypertrophy, as shown by the ratio of HW (heart weight)/BW (bodyweight) (Figure 5A,B) and LV mass measured by echocardiography (Figure 5E).