ATM, ATRX, BARD1, BRCA2, ERCC3, MSH2, MSH6, PMS2, and POLE were more frequently altered in IBC, in which we found also frequent alterations of TP53, FANCA, and FANCB. This observation confirms recent findings (Liang et al., 2018) of frequent alterations in BRCA1/BRCA2/POLE genes in IBC. The gene discussed is POLE; the disease is inflammatory breast carcinoma.