The 10 most frequently altered genes in IBC are TP53 (63%), HER2 (30%), MYC (27%), PIK3CA (21%), BRCA2 (14%), CCND1 (13%), GATA3 (13%), NOTCH1 (12%), FGFR1 (11%), and ARID1A (10%), which are also altered in non‐IBC. The gene discussed is NOTCH1; the disease is inflammatory breast carcinoma.