IDH2 and astrocytoma (excluding glioblastoma): Furthermore, recent literature also demonstrates that IDH-mutated astrocytomas have higher ADC [46–48] and lower rCBV values [47–49], an APT signal [15, 16], the relaxation-weighted sodium signal to total sodium signal ratio [17], oxygen extraction fraction [50], and tumor stiffness [18] than IDH wild-type tumors.