Due to the higher abundance of αSyn compared with Aβ or tau, a column-based batch IP method was employed (Supplementary Figure 9c) and this removed all ELISA (Fig. 8e, g) and Western blot (Supplementary Figure 9D; DLB2) detectable αSyn from the DLB extracts. This evidence concerns the gene DLEU2 and Lewy body dementia.