ESR1 and neoplasm: Higher relative amounts of E2 and E1 were detected in adipose tissue of women with ER+/PR+ tumor than in women with ER–/PR– tumor (P = .0163 and P = .0134, respectively) (Fig. 3E) (postmenopausal, n = 11, P = .1077 and P = .4324, respectively; premenopausal, no convergence).