When the percentage of synapses co-localizing with clusterin was examined, we observed an increase in Alzheimer’s disease cases compared with controls with the largest effect near plaques in APOE4 carriers (Fig. 4C, Kruskal–Wallis test χ2(4) = 21.16, P = 0.0003; post hoc Mann–Whitney U between Alzheimer's disease APOE3 near and APOE3 far P = 0.0286, between Alzheimer's disease APOE4 near and APOE4 far P = 0.0023, between Alzheimer's disease APOE3 far and Alzheimer's disease APOE4 far P = 0.012, and between control and APOE4 far P = 0.0025). The gene discussed is APOE; the disease is Alzheimer disease.