APOE and Alzheimer disease: The predictive value of synaptic or neurodegeneration CSF biomarkers for longitudinal change during up to four years of follow-up on the MDRS, CVLT (immediate and delayed recall) and CDR-sb in patients with MCI or AD was examined using linear mixed effect models that included demographics, APOE ε4 and CSF Aβ1-42 and Tau levels (selected relationships are shown in Fig. 3, and all relationships are shown in Table 2) and then added each synaptic marker to this model.