MTDH and diabetic cardiomyopathy: Zhao et al. found that the of AEG-1 expression was up-regulated in streptozocin-induced diabetic cardiomyopathy mice (Zhao et al. 2018) Furthermore, Peng et al. reported that AEG-1 low-expression could suppresses NLRP3 expression and promote caspase-1 activation, which further reduced the levels of IL-1β and IL-18.