Overall life expectancy is increasing worldwide and the majority of the population isexperiencing continuous weight gain.1 This prevailing development results in a dramatic increase in the globalincidence of diabetes mellitus.2 Although type 1 diabetes is characterized by insulin deficiency caused byautoimmune beta cell destruction in the endocrine pancreas, type 2 diabetes ischaracterized by insulin resistance with high insulin levels in its early stageswhich results in impaired insulin production in later stages. Here, INS is linked to diabetes mellitus.