Consistently, PB CD4+CXCR5+ Tfh and CD4+CXCR5+ICOS+ Tfh levels from ITP patients were also higher than from HCs (CD4+CXCR5+: 17.01 ± 4.47 % vs. 10.01 ± 0.60 %, P = 0.001; CD4+CXCR5+ICOS+: 3.21 ± 1.75 % vs. 1.18 ± 0.19 %, P = 0.036; Figure 5G and H). This evidence concerns the gene ICOS and autoimmune thrombocytopenic purpura.