It is well known that Th subset balance in peripheral blood (PB) of ITP patients is disrupted, and increased numbers of circulating Th1, Th17, Th22 cells, as well as reduced number or function of CD4+CD25+FoxP3+ regulatory T cells (Tregs) has been reported 8-10. This evidence concerns the gene CD4 and autoimmune thrombocytopenic purpura.