Since the AD mouse model varies widely in the published literature, a pilot study was executed, in which different concentrations of AngII minipump with or without BAPN treatment were tested in 8 weeks old male ApoE-/- mice, finally, the 14 days of 2,500 ng/min/kg Ang II with 21 days of BAPN treatment group has the highest incidence of AD among the tested groups (Figure S1A-B), thus this model was chosen for the following experiment. The gene discussed is APOE; the disease is Alzheimer disease.