BRCA2 and breast cancer: Although many of the factors related to breast and ovarian cancer were significant predictors of pathogenicity for both genes and across all races and ethnicities, there were a few differences, particularly with regard to pancreatic cancer and male breast cancer, which were shown to be important predictors for BRCA2, but not BRCA1. Interestingly, DCIS alone in the index case and having first-degree relatives with breast cancer over age 50 were predictors of the absence of a BRCA1 pathogenic variant, but predictors of the presence of a BRCA2 pathogenic variant.