For all racial and ethnic groups, the area under the receiver–operator curve (AUC) for the predicted pathogenic variant status were higher for BRCA1 (0.79–0.83) than for BRCA2 (0.66–0.70), due primarily to the higher predictive power of ovarian cancer and the association with triple-negative breast cancer in BRCA1. For BRCA1, the African American sample had the highest AUC (0.83), which was significantly higher than that for Caucasians. Here, BRCA2 is linked to triple-negative breast carcinoma.