However, other symptoms of DM1, such as cardiomyocyte defects, cataracts, and abnormalities of diaphragm muscle and small intestine (Fig. 2i), cannot be observed in Dmwd+/− mice, suggesting that DMWD is not sufficient to account for all the complex multisystem symptoms of DM1. This evidence concerns the gene DMWD and myotonic dystrophy type 1.